Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

@article{Riethmacher1997SevereNI,
  title={Severe neuropathies in mice with targeted mutations in the ErbB3 receptor},
  author={Dieter Riethmacher and Eva Sonnenberg-Riethmacher and Volker Brinkmann and Tomoichiro Yamaai and Gary R. Lewin and Carmen Birchmeier},
  journal={Nature},
  year={1997},
  volume={389},
  pages={725-730}
}
Neuregulins and their specific receptors, members of the ErbB family of tyrosine kinases, have been implicated in the control of growth and development of Schwann cells, specialized cells that wrap around nerve axons to provide electrical insulation. Here we use gene targeting to generate mice that lack ErbB3, a high-affinity neuregulin receptor. Homozygous erbB3 mutant embryos lack Schwann-cell precursors and Schwann cells that accompany peripheral axons of sensory and motor neurons. The… 
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