Severe motor neuron degeneration in the spinal cord of the Tg2576 mouse model of Alzheimer disease.

@article{Seo2010SevereMN,
  title={Severe motor neuron degeneration in the spinal cord of the Tg2576 mouse model of Alzheimer disease.},
  author={Ji-Seon Seo and Yea-Hyun Leem and Kang-Woo Lee and Seung-Woo Kim and Ja-Kyeong Lee and Pyung-Lim Han},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={21 1},
  pages={263-76}
}
The transgenic mouse Tg2576 is widely used as a murine model of Alzheimer's disease (AD) and exhibits plaque pathogenesis in the brain and progressive memory impairments. Here we report that Tg2576 mice also have severe spinal cord deficits. At 10 months of age, Tg2576 mice showed a severe defect in the hindlimb extension reflex test and abnormal body trembling and hindlimb tremors when suspended by the tail. The frequency and severity of these abnormalities were overt at 10 months of age and… CONTINUE READING