Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders.

@article{Azakami2009SevereLO,
  title={Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders.},
  author={Kazuko Azakami and Tomoo Sato and Natsumi Araya and Atae Utsunomiya and Ryuji Kubota and Kenshi Suzuki and Daisuke Hasegawa and Toshihiko Izumi and Hidetoshi Fujita and Satoko Aratani and Ryoji Fujii and Naoko Yagishita and Hajime Kamijuku and Takuro Kanekura and Ken-ichiro Seino and Kusuya Nishioka and Toshihiro Nakajima and Yoshihisa Yamano},
  journal={Blood},
  year={2009},
  volume={114 15},
  pages={
          3208-15
        }
}
Invariant natural killer T (iNKT) cells are unique T cells that regulate the immune response to microbes, cancers, and autoimmunity. We assessed the characteristics of iNKT cells from persons infected with human T-lymphotropic virus type 1 (HTLV-1). Whereas most infected persons remain asymptomatic carriers (ACs) throughout their lives, a small proportion, usually with high equilibrium proviral loads,develop 2 diseases: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and… CONTINUE READING
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