Severe lactic acidosis treated with prolonged hemodialysis: recovery after massive overdoses of metformin.

@article{Guo2006SevereLA,
  title={Severe lactic acidosis treated with prolonged hemodialysis: recovery after massive overdoses of metformin.},
  author={Peter Y F Guo and Leroy J. Storsley and Simon Neil Finkle},
  journal={Seminars in dialysis},
  year={2006},
  volume={19 1},
  pages={80-3}
}
We report two cases of severe lactic acidosis due to massive metformin ingestion. The first case was a 37-year-old man who was discovered several hours after ingesting 45 g of metformin. He had severe lactic acidosis (blood pH 6.81, bicarbonate 4 mEq/L, lactate 25.7 mEq/L). Despite intravenous bicarbonate therapy, he decompensated and was placed on a combination of hemodialysis and charcoal hemoperfusion for a continuous time of 25 hours. His hospital course was complicated by acute renal… CONTINUE READING