Severe insulin resistance: pathologies

  title={Severe insulin resistance: pathologies},
  author={Audrey Melvin and Anna J. Stears},
  journal={Practical Diabetes},
In parallel with the increasing prevalence of obesity, rates of insulin resistance and its associated complications have increased; however, insulin resistance is not only a disease of the overweight and obese. Disorders of adipose tissue expandability and insulin receptor signalling cause syndromes of severe insulin resistance that may go unrecognised in clinical practice but whose metabolic complications are significant and often the initial presentation of the condition. 



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