Severe hypophosphatemic osteomalacia in hormone-refractory prostate cancer metastatic to the skeleton: natural history and pitfalls in management.

@article{Pelger2005SevereHO,
  title={Severe hypophosphatemic osteomalacia in hormone-refractory prostate cancer metastatic to the skeleton: natural history and pitfalls in management.},
  author={Rob C. M. Pelger and Guus a B Lycklama A Nijeholt and Socrates E Papapoulos and N A Hamdy},
  journal={Bone},
  year={2005},
  volume={36 1},
  pages={1-5}
}
We report the case of a severe symptomatic hypophosphatemic osteomalacia in a 66-year-old patient with hormone-refractory prostate cancer metastatic to the skeleton. A follow-up of 2 years from diagnosis to development of hormone refractoriness and death allowed us to study the natural history of this uncommon disturbance of mineral homeostasis in this common malignancy. Relevant to the difficult management of the late stages of prostate cancer is the failure of hypophosphatemia to respond to… CONTINUE READING