Severe hypodiploidy with karyotype instability in a case of acute myeloid leukemia.

@article{Betts1994SevereHW,
  title={Severe hypodiploidy with karyotype instability in a case of acute myeloid leukemia.},
  author={David R. Betts and O H Baugh and Brian Gibbons},
  journal={Cancer genetics and cytogenetics},
  year={1994},
  volume={74 2},
  pages={
          147-9
        }
}
We present a case of acute myeloid leukemia (AML) in an elderly male. A severe hypodiploid karyotype (chromosome range 29-39) was detected with a large amount of cell-to-cell variation, suggesting that the leukemic cells are primarily characterized by chromosomal loss due to karyotypic instability. Severe hypodiploidy is a rare finding in AML but previous similar cases indicate that it confers a very poor prognosis. 

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