Severe hypertension caused by alleles from normotensive Lewis for a quantitative trait locus on chromosome 2.

@article{Eliopoulos2005SevereHC,
  title={Severe hypertension caused by alleles from normotensive Lewis for a quantitative trait locus on chromosome 2.},
  author={Vasiliki Eliopoulos and Julie Dutil and Yishu Deng and Myrian Grondin and Alan Y. Deng},
  journal={Physiological genomics},
  year={2005},
  volume={22 1},
  pages={70-5}
}
Pursuing fully a suggestion from linkage analysis that there might be a quantitative trait locus (QTL) for blood pressure (BP) in a chromosome (Chr) 2 region of the Dahl salt-sensitive rat (DSS), four congenic strains were made by replacing various fragments of DSS Chr 2 with those of Lewis (LEW). Consequently, a BP QTL was localized to a segment of around 3 cM or near 3 Mb on Chr 2 by comparative congenics. The BP-augmenting alleles of this QTL originated from the LEW rat, a normotensive… CONTINUE READING

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