Severe hypersensitivity reaction upon rechallenge with trimethoprim-sulfamethoxazole in a patient with AIDS.

@article{Arnold1988SevereHR,
  title={Severe hypersensitivity reaction upon rechallenge with trimethoprim-sulfamethoxazole in a patient with AIDS.},
  author={Paige A. Arnold and B. Joseph Guglielmo and Harry Hollander},
  journal={Drug intelligence & clinical pharmacy},
  year={1988},
  volume={22 1},
  pages={43-5}
}
A patient with acquired immunodeficiency syndrome (AIDS) developed rash, fever, neutropenia, and elevated liver function tests during an initial course of trimethoprim-sulfamethoxazole (TMP-SMX) therapy. Upon reexposure to the drug, the patient experienced a severe anaphylactoid reaction associated with pulmonary edema and rhabdomyolysis. Reactions… CONTINUE READING