Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system.

@article{Bandulik2013SevereHI,
  title={Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system.},
  author={Sascha Bandulik and Philipp Tauber and David Penton and Frank Schweda and Ines Tegtmeier and Christina Sterner and Enzo Lalli and Florian Lesage and Michaela F. Hartmann and Jacques Barhanin and Richard Warth},
  journal={Endocrinology},
  year={2013},
  volume={154 8},
  pages={2712-22}
}
Task3 K(+) channels are highly expressed in the adrenal cortex and contribute to the angiotensin II and K(+) sensitivity of aldosterone-producing glomerulosa cells. Adult Task3(-/-) mice display a partially autonomous aldosterone secretion, subclinical hyperaldosteronism, and salt-sensitive hypertension. Here, we investigated the age dependence of the adrenal phenotype of Task3(-/-) mice. Compared with adults, newborn Task3(-/-) mice displayed a severe adrenal phenotype with strongly increased… CONTINUE READING
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