Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: a study of a cohort of 14,000 mutation carriers.

@article{Besseling2014SevereHF,
  title={Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: a study of a cohort of 14,000 mutation carriers.},
  author={Joost Besseling and Iris Kindt and Michel H. Hof and John J. P. Kastelein and Barbara A. Hutten and G. K. Hovingh},
  journal={Atherosclerosis},
  year={2014},
  volume={233 1},
  pages={219-23}
}
BACKGROUND Some recently emerged lipid-lowering therapies are currently restricted to patients with homozygous familial hypercholesterolemia (HoFH), and studies are underway to also assess these therapies in patients with 'severe heterozygous FH (HeFH)'. However, no uniform definition of 'severe HeFH' exists, although untreated low-density lipoprotein cholesterol (LDL-C) levels above 8 mmol/L (309 mg/dl) have been historically used to define this phenotype. Our aim was to define severe HeFH, to… CONTINUE READING
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