Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration

Abstract

The use of so-called ‘suicide’ genes to activate prodrugs has been effective in animal models for several solid tumor types and is now in phase I and II clinical trials. We have exploited adenovirus vectors (Ad) for transfer and expression of the herpes simplex virus thymidine kinase (HSVtk) gene to render rat colorectal liver metastases sensitive to the… (More)
DOI: 10.1038/sj.gt.3300637

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@article{Eb1998SevereHD, title={Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration}, author={M M van der Eb and S. Cramer and Yvonne Vergouwe and FHE Schagen and J. H. J. M. van Krieken and AJ van der Eb and IHM Borel Rinkes and CJH van de Velde and RC Hoeben}, journal={Gene Therapy}, year={1998}, volume={5}, pages={451-458} }