Severe hearing loss in Dlxl mutant mice.

  title={Severe hearing loss in Dlxl mutant mice.},
  author={Daniel B Polley and Inma Cobos and Michael Merzenich and John L R Rubenstein},
  journal={Hearing research},
  volume={214 1-2},
The Dlx homeobox gene family participates in regulating middle and inner ear development. A significant role for Dlxl, in particular,has been demonstrated in the development of the middle ear ossicles, but the functional consequences of Dlx.l gene mutation on hearing thresholds has not been assessed. The present study characterizes auditory brainstem responses to click and tonal stimuli in a non-lethal variant of a Dlxl gene knockout. We found that peripheral hearing thresholds for click and… CONTINUE READING