Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy").

@article{Ricaurte2002SevereDN,
  title={Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy").},
  author={George A. Ricaurte and Jie Yuan and George Hatzidimitriou and Branden J. Cord and Una D. McCann},
  journal={Science},
  year={2002},
  volume={297 5590},
  pages={2260-3}
}
The prevailing view is that the popular recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, or "ecstasy") is a selective serotonin neurotoxin in animals and possibly in humans. Nonhuman primates exposed to several sequential doses of MDMA, a regimen modeled after one used by humans, developed severe brain dopaminergic neurotoxicity, in addition to less pronounced serotonergic neurotoxicity. MDMA neurotoxicity was associated with increased vulnerability to motor dysfunction secondary… CONTINUE READING

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