Severe digital necrosis in an elderly patient with heterozygous factor V Leiden mutation.

@article{Patel2000SevereDN,
  title={Severe digital necrosis in an elderly patient with heterozygous factor V Leiden mutation.},
  author={Girish K. Patel and E V Morris and Mohamed Rosli Abdul Rashid and Alexander V. Anstey},
  journal={The British journal of dermatology},
  year={2000},
  volume={143 6},
  pages={1302-5}
}
We report an 81-year-old female with a heterozygous factor V Leiden mutation who developed purpura fulminans. Digital necrosis, a characteristic clinical feature of purpura fulminans was prominent. Purpura fulminans is more common in children and adult cases are rare. Of eight reported cases of purpura fulminans resulting from a heterozygous factor V Leiden mutation recorded in the literature, only two were in adults: 40 and 42 years of age, respectively. This is the first report of this… CONTINUE READING