Severe diabetes inhibits resistance exercise-induced increase in eukaryotic initiation factor 2B activity.

@article{Kostyak2001SevereDI,
  title={Severe diabetes inhibits resistance exercise-induced increase in eukaryotic initiation factor 2B activity.},
  author={John Creigh Kostyak and Scot R. Kimball and Leonard S. Jefferson and Peter A. T. Farrell},
  journal={Journal of applied physiology},
  year={2001},
  volume={91 1},
  pages={79-84}
}
Rates of protein synthesis are reduced in severely diabetic rats. A potential mechanism through which insulin can stimulate protein synthesis is modulation of the activity of eukaryotic initiation factor 2B (eIF2B). The activity of this factor is elevated after exercise in nondiabetic rats but is markedly lower in skeletal muscle from nonexercised severely diabetic rats. We tested the hypothesis that a failure to increase eIF2B activity after exercise is one potential reason for a failure of… CONTINUE READING
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