Severe destructive autoimmune lesions with aging in murine Sjögren's syndrome through Fas-mediated apoptosis.


When we evaluated the age-associated changes in autoimmune exocrinopathy in a NFS/sld murine model for primary Sjögren's syndrome (SS), severe destructive autoimmune lesions developed in the salivary and lacrimal glands in the aged mice, compared with those observed in the younger model. We detected a decreased secretion of saliva and tear flow in the aged… (More)


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@article{Ishimaru2000SevereDA, title={Severe destructive autoimmune lesions with aging in murine Sj{\"{o}gren's syndrome through Fas-mediated apoptosis.}, author={Naozumi Ishimaru and Toshiyuki Yoneda and Kaoru Saegusa and Kazunori Yanagi and Norio Haneji and Kayano Moriyama and Isao Saito and Yuichiro Hayashi}, journal={The American journal of pathology}, year={2000}, volume={156 5}, pages={1557-64} }