Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency.

@article{Kawamura2012SevereDW,
  title={Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency.},
  author={Tatsuyoshi Kawamura and Youichi Ogawa and Yuumi Nakamura and Satoshi Nakamizo and Yoshihiro Ohta and Hajime Nakano and Kenji Kabashima and Ichiro Katayama and Schuichi Koizumi and Tatsuhiko Kodama and Atsuhito Nakao and Shinji Shimada},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 2},
  pages={722-32}
}
Zinc deficiency can be an inherited disorder, in which case it is known as acrodermatitis enteropathica (AE), or an acquired disorder caused by low dietary intake of zinc. Even though zinc deficiency diminishes cellular and humoral immunity, patients develop immunostimulating skin inflammation. Here, we have demonstrated that despite diminished allergic contact dermatitis in mice fed a zinc-deficient (ZD) diet, irritant contact dermatitis (ICD) in these mice was more severe and prolonged than… CONTINUE READING
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