Severe clinical toxicity associated with analytically confirmed recreational use of 25I–NBOMe: case series

@article{Hill2013SevereCT,
  title={Severe clinical toxicity associated with analytically confirmed recreational use of 25I–NBOMe: case series},
  author={Simon L Hill and Tom Doris and Shivaraj Gurung and Stephen Katebe and Alexander Lomas and Michael P. Dunn and Peter G. Blain and Simon H L Thomas},
  journal={Clinical Toxicology},
  year={2013},
  volume={51},
  pages={487 - 492}
}
Abstract Context. 4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe) is a N-methoxybenzyl-substituted phenethylamine with potent serotoninergic effects. We describe seven cases of analytically confirmed toxicity due to the recreational use of 25I-NBOMe in the United Kingdom. Case series. Seven patients, all young adult males, presented to hospitals in the northeast of England with clinical toxicity after recreational drug use in January 2013. Clinical features included… 

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References

SHOWING 1-9 OF 9 REFERENCES

A case of 25I-NBOMe (25-I) intoxication: a new potent 5-HT2A agonist designer drug

A case of self-reported exposure to 25-I (25I-NBOMe), a novel phenethylamine derivative, with subsequent quantification in serum is described, a potent new synthetic drug with apparent significant behavioral toxicity that can be detected and quantified in serum.

Radiosynthesis and Evaluation of 11C-CIMBI-5 as a 5-HT2A Receptor Agonist Radioligand for PET

11C-CIMBI-5 is a promising tool for investigation of 5-HT2A agonist binding in the living human brain and has a sufficient target-to-background ratio for future clinical use and is displaceable by ketanserin in both rats and pigs.

Molecular Interaction of Serotonin 5-HT2A Receptor Residues Phe339(6.51) and Phe340(6.52) with Superpotent N-Benzyl Phenethylamine Agonists

This study is the first to identify a hitherto unrecognized role for residue 6.51 in agonist activation of a serotonin G protein-coupled receptor (GPCR), whereas most previous reports have suggested a varied and sometimes contradictory role in homologous GPCRs.

25-I, a novel substituted amphetamine

  • Clin Toxicol
  • 2012

Case series of 25I-NBOMe 8. exposures with laboratory confi rmation

    Synthese und Pharmakologie potenter 5-HT2A-Rezeptorag-1. onisten mit N-2-Methoxybenzyl-Partialstruktur . Dissertation

      Severe poisoning 7. following self-reported use of 25-I, a novel substituted amphetamine