Severe chronic autoimmune thrombocytopenic purpura is associated with an expansion of CD56+ CD3- natural killer cells subset.

@article{GarcaSurez1993SevereCA,
  title={Severe chronic autoimmune thrombocytopenic purpura is associated with an expansion of CD56+ CD3- natural killer cells subset.},
  author={Julio Garc{\'i}a-Su{\'a}rez and A. Fern{\'e}ndez Prieto and Eduardo Dopico Reyes and Luis Armando Ibarra Manzano and Javier Llorente Merino and Melchor {\'A}lvarez-Mon},
  journal={Blood},
  year={1993},
  volume={82 5},
  pages={
          1538-45
        }
}
Recent studies have indicated that autoimmune thrombocytopenic purpura (ATP) patients show immune system alterations that are not restricted to the B-cell compartment, but that also affect T lymphocytes. This report studies the phenotypic characteristics of natural killer (NK) cells in the peripheral blood of ATP patients, as well as their clinical significance in 33 ATP patients with active disease. Ten patients had stable disease (sustained platelet counts > 50,000/microL without the need for… CONTINUE READING

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