Corpus ID: 24025168

Severe atovaquone-resistant Plasmodium falciparum malaria in a Canadian traveller returned from the Indian subcontinent

@inproceedings{Perry2009SevereAP,
  title={Severe atovaquone-resistant Plasmodium falciparum malaria in a Canadian traveller returned from the Indian subcontinent},
  author={Thomas L. Perry and Prativa Pandey and Jennifer M. Grant and Kevin C Kain},
  booktitle={Open medicine : a peer-reviewed, independent, open-access journal},
  year={2009}
}
  • Thomas L. Perry, Prativa Pandey, +1 author Kevin C Kain
  • Published in
    Open medicine : a peer…
    2009
  • Medicine
  • BACKGROUND We report the first case of atovaquone/proguanil treatment failure in severe Plasmodium falciparum malaria acquired by a non-immune traveller to the Indian subcontinent. Recrudescent infection was complicated by neurological involvement 14 days after directly observed therapy with atovaquone/proguanil. Sequence analysis of the plasmodial cytochrome b gene confirmed a contribution of atovaquone resistance to treatment failure. The recrudescent isolate had a single mutation at position… CONTINUE READING

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