Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population.

@article{Czarnowicki2015SevereAD,
  title={Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population.},
  author={T Czarnowicki and J. Seoane Gonzalez and Avner Shemer and Dana Malajian and Hui Xu and X Zheng and Saakshi Khattri and Patricia M Gilleaudeau and Mary M Sullivan-Whalen and Mayte Su{\'a}rez-Fari{\~n}as and James G. Krueger and Emma Guttman-Yassky},
  journal={The Journal of allergy and clinical immunology},
  year={2015},
  volume={136 1},
  pages={104-115.e7}
}
BACKGROUND Past studies of blood T-cell phenotyping in patients with atopic dermatitis (AD) have provided controversial results and were mostly performed before the identification of TH9, TH17, and TH22 T-cell populations in human subjects. OBJECTIVE We sought to quantify TH1, TH2, TH9, TH17, and TH22 T-cell populations and corresponding CD8(+) T-cell subsets in both cutaneous lymphocyte antigen (CLA)-positive and CLA(-) T-cell subsets in patients with AD and control subjects. METHODS We… CONTINUE READING
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