Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein

@article{Marotti1993SevereAI,
  title={Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein},
  author={Keith R. Marotti and Christine K. Castle and Timothy P. Boyle and Alice H. Lin and Robert W. Murray and George W. Melchior},
  journal={Nature},
  year={1993},
  volume={364},
  pages={73-75}
}
CHOLESTERYL ester transfer protein (CETP) is a plasma protein that mediates the exchange of neutral lipids among the lipoproteins1–3. Because the principal core lipid of very-low-density lipoprotein (VLDL) is triglyceride and that of high-density lipoprotein (HDL) is cholesterol ester, CETP mediates a 'heteroexchange' of cholesterol ester for triglyceride between those lipoproteins. As a result, animals that express CETP tend to have higher VLDL and low-density lipoprotein (LDL) cholesterol… CONTINUE READING