Severe asthma and the omalizumab option

  title={Severe asthma and the omalizumab option},
  author={Christopher W T Miller and Narayanaswamy Krishnaswamy and Chambless R Johnston and G. Krishnaswamy},
  journal={Clinical and molecular allergy : CMA},
  pages={4 - 4}
Atopic diseases and asthma are increasing at a remarkable rate on a global scale. It is now well recognized that asthma is a chronic inflammatory disease of the airways. The inflammatory process in many patients is driven by an immunoglobulin E (IgE)-dependent process. Mast cell activation and release of mediators, in response to allergen and IgE, results in a cascade response, culminating in B lymphocyte, T lymphocyte, eosinophil, fibroblast, smooth muscle cell and endothelial activation. This… CONTINUE READING


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