Severe and anxious depression: combining definitions of clinical sub-types to identify patients differentially responsive to selective serotonin reuptake inhibitors.

@article{Papakostas2012SevereAA,
  title={Severe and anxious depression: combining definitions of clinical sub-types to identify patients differentially responsive to selective serotonin reuptake inhibitors.},
  author={George I. Papakostas and Hua Fan and Enrico Tedeschini},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2012},
  volume={22 5},
  pages={347-55}
}
Patients with severe major depressive disorder are more likely than those with mild/moderate depression to experience the relative benefits of antidepressant therapy versus placebo. Several studies have, unexpectedly, failed to show a similar antidepressant-placebo discrepancy between patients with versus without anxious depression, although patients with anxious depression are more likely to meet criteria for severe depression than those without. The aim of this study was to confirm the… CONTINUE READING

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Testing anxious MDD as a predictor and moderator of symptom improvement in MDD

  • G. I. Papakostas, K. Larsen
  • Poster presented at the Congress of the American…
  • 2009
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