Severe and Difficult‐to‐Treat Asthma in Adults

@article{Israel2017SevereAD,
  title={Severe and Difficult‐to‐Treat Asthma in Adults},
  author={Elliot Israel and Helen K. Reddel},
  journal={The New England Journal of Medicine},
  year={2017},
  volume={377},
  pages={965–976}
}
Adults with severe asthma consume substantial human and financial resources. This review examines the biology, current diagnosis, and treatment of this multifaceted condition. 
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ncbi.nlm.nih.gov
253 Citations
Highly Influential Citations
15
Background Citations
84
Methods Citations
2

253 Citations

Escalating Inhaled Glucocorticoids to Prevent Asthma Exacerbations.
  • P. Bardin
  • Medicine
    The New England journal of medicine
  • 2018
Inhaled glucocorticoids are pivotal to achieve asthma control and disease stability in both children and adults; despite their use, with or without other treatments, many patients with asthma have ...
Variability of blood eosinophils in patients in a clinic for severe asthma
  • Ewa RakowskiSibo Zhao J. Reibman
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2019
Blood eosinophils are used to determine eligibility for agents targeting IL‐5 in patients with uncontrolled asthma. However, little is known about the variability of blood eosinophil measures in…
Involvement of the epidermal growth factor receptor in IL‐13–mediated corticosteroid‐resistant airway inflammation
TLDR
Effective treatment for severe asthma is a significant unmet need because many severe asthmatics exhibit corticosteroid‐unresponsive mixed granulocytic inflammation.
Addressing Comorbidities in Difficult Asthma
TLDR
The conditions discussed in this chapter will be allergic rhinitis, chronic rhinosinusitis with or without nasal polyps, aspirin-exacerbated respiratory disease, obstructive sleep apnea, gastroesophageal reflux disease/laryngopharyngealReflux disease, and vocal cord dysfunction.
Update on Diagnosis and Management of Severe Asthma
  • J. Muhrer
  • Medicine
    The Journal for Nurse Practitioners
  • 2018
Integrating Type 2 Biologics in the Management of Uncontrolled Severe Asthma: The Importance of Lung Function in Disease Control
TLDR
Dupixent (dupilumab) prescribing information is presented at ATS, San Diego, California, USA, May 17–22, 2019.
The Tempest: Difficult to Control Asthma in Adolescence.
Biological treatments for severe asthma: where do we stand?
  • W. Busse
  • Medicine, Biology
    Current opinion in allergy and clinical immunology
  • 2018
TLDR
For patients with severe asthma and biomarkers indicating a type 2 inflammatory pathway, the addition of biologics has proven to be an effective approach to achieve disease control and is an appropriate next step treatment.
Managing the overlap of asthma and chronic obstructive pulmonary disease
TLDR
Patients with obstructive lung disease have features of both asthma and chronic obstructive pulmonary disease and inhaled corticosteroids are key to the management of asthma, and they are recommended in patients with overlapping chronic obstructives pulmonary disease.
Smoking asthmatics, a neglected large phenotype of asthmatic patients
TLDR
Findings from the Still Fighting for Breath global survey regarding the prevalence of smoking in patients with severe asthma, impact of smoking on asthma control and correlation of smoking with different aspects of quality of life in Patients with severe persistent asthma are presented.
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