Severe adverse effects in a newborn with two defective CYP2D6 alleles after exposure to paroxetine during late pregnancy.

@article{Laine2004SevereAE,
  title={Severe adverse effects in a newborn with two defective CYP2D6 alleles after exposure to paroxetine during late pregnancy.},
  author={Kari Laine and Jaakko Kyt{\"o}l{\"a} and Leif Bertilsson},
  journal={Therapeutic drug monitoring},
  year={2004},
  volume={26 6},
  pages={685-7}
}
Paroxetine, like other SSRIs, is reported not to increase the number of malformations in infants exposed to these drugs in utero. However, late pregnancy exposure to SSRIs sometimes leads to perinatal complications resembling the symptoms seen in serotonergic overstimulation. We report here a case of third trimester paroxetine exposure with adverse birth outcome in a newborn. The clinical symptoms in the infant included severe tremor and rigidity as well as loose stools during the first 4 days… CONTINUE READING