Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain.

@article{Schneider2012SevereAR,
  title={Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain.},
  author={Martha Schneider and Kerstin Ackermann and Melissa A Stuart and Claudia Wex and Ulrike Protzer and Hermann M Sch{\"a}tzl and Sabine Gilch},
  journal={Journal of virology},
  year={2012},
  volume={86 18},
  pages={10112-22}
}
The ubiquitin-proteasome system (UPS) is involved in the replication of a broad range of viruses. Since replication of the murine hepatitis virus (MHV) is impaired upon proteasomal inhibition, the relevance of the UPS for the replication of the severe acute respiratory syndrome coronavirus (SARS-CoV) was investigated in this study. We demonstrate that the proteasomal inhibitor MG132 strongly inhibits SARS-CoV replication by interfering with early steps of the viral life cycle. Surprisingly… CONTINUE READING