Severe acute respiratory syndrome coronavirus persistence in Vero cells.

@article{Palacios2005SevereAR,
  title={Severe acute respiratory syndrome coronavirus persistence in Vero cells.},
  author={Gustavo Palacios and Omar Jabado and Neil Renwick and Thomas Briese and W. Ian Lipkin},
  journal={Chinese medical journal},
  year={2005},
  volume={118 6},
  pages={451-9}
}
BACKGROUND Several coronaviruses establish persistent infections in vitro and in vivo, however it is unknown whether persistence is a feature of the severe acute respiratory syndrome coronavirus (SARS-CoV) life cycle. This study was conducted to investigate viral persistence. METHODS We inoculated confluent monolayers of Vero cells with SARS-CoV at a multiplicity of infection of 0.1 TCID50 and passaged the remaining cells every 4 to 8 days for a total of 11 passages. Virus was titrated at… CONTINUE READING

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