Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane.

@article{Frieman2007SevereAR,
  title={Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane.},
  author={Matthew B. Frieman and Boyd L. Yount and Mark Heise and Sarah A. Kopecky-Bromberg and P. Palese and Ralph S. Baric},
  journal={Journal of virology},
  year={2007},
  volume={81 18},
  pages={9812-24}
}
The host innate immune response is an important deterrent of severe viral infection in humans and animals. Nuclear import factors function as key gatekeepers that regulate the transport of innate immune regulatory cargo to the nucleus of cells to activate the antiviral response. Using severe acute respiratory syndrome coronavirus (SARS-CoV) as a model, we demonstrate that SARS-COV ORF6 protein is localized to the endoplasmic reticulum (ER)/Golgi membrane in infected cells, where it binds to and… CONTINUE READING

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