Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex.

@article{Siu2009SevereAR,
  title={Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex.},
  author={K T Siu and Kin-Hang Kok and M. J. Ng and Vincent Kwok-Man Poon and Kwok-yung Yuen and Bo-jian Zheng and Dong-Yan Jin},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 24},
  pages={16202-9}
}
Severe acute respiratory syndrome (SARS) coronavirus is highly pathogenic in humans and evades innate immunity at multiple levels. It has evolved various strategies to counteract the production and action of type I interferons, which mobilize the front-line defense against viral infection. In this study we demonstrate that SARS coronavirus M protein inhibits gene transcription of type I interferons. M protein potently antagonizes the activation of interferon-stimulated response element… CONTINUE READING

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