Severe Spinal Cord Injury Causes Immediate Multi-cellular Dysfunction at the Chondro-Osseous Junction

@article{Morse2011SevereSC,
  title={Severe Spinal Cord Injury Causes Immediate Multi-cellular Dysfunction at the Chondro-Osseous Junction},
  author={Leslie R. Morse and Yan Xu and Bethlehem Solomon and Lara M. Boyle and Subbiah Yoganathan and Philip P. Stashenko and Ricardo A. Battaglino},
  journal={Translational Stroke Research},
  year={2011},
  volume={2},
  pages={643-650}
}
Spinal cord injury is associated with rapid bone loss and arrested long bone growth due to mechanisms that are poorly understood. In this study, we sought to determine the effects of severe T10 contusion spinal cord injury on the sublesional bone microenvironment in adolescent rats. A severe lower thoracic (vertebral T10) spinal cord injury was generated by weight drop (10 g × 50 mm). Severely injured and body weight-matched uninjured male Sprague–Dawley rats were studied. At 3 and 5 days post… CONTINUE READING

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