Severe Pyridoxine Deficiency: A Model for Ataxia Telangiectasia

@article{Nelson1970SeverePD,
  title={Severe Pyridoxine Deficiency: A Model for Ataxia Telangiectasia},
  author={Thomas Edward Nelson and Starkey D Davis and Thomas H. Shepard},
  journal={Pediatric Research},
  year={1970},
  volume={4},
  pages={441-441}
}
The association of neural, vasculr, and immunologic abnormalities in ataxia telangiectasia is unexplained. We studied the teratogenic effects of B6 as an experimental model because it is associated with (1) neonatal convulsions and (2) impaired immunologic response in rats. Pregnant rats were given a B6-deficient diet and 4-desoxypyridoxine, an inhibitor of… CONTINUE READING