Severe Listeria monocytogenes infection induces development of monocytes with distinct phenotypic and functional features.

@article{Drevets2010SevereLM,
  title={Severe Listeria monocytogenes infection induces development of monocytes with distinct phenotypic and functional features.},
  author={Douglas A. Drevets and Jennifer E. Schawang and Vinay K Mandava and Marilyn J. Dillon and Pieter J. M. Leenen},
  journal={Journal of immunology},
  year={2010},
  volume={185 4},
  pages={
          2432-41
        }
}
Monocytes perform diverse roles during infection with the facultative intracellular bacterium Listeria monocytogenes. They are essential as bactericidal cells in host defense but can also become Trojan horses transporting bacteria into the brain. To explain these contrasting roles, we characterized bone marrow (BM) monocytes in steady state and generated during lethal and sublethal L. monocytogenes infection. Ly-6C(high)CD11b(+) BM monocytes expressed high amounts of M-CSFR/CD115 in steady… CONTINUE READING

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