Severe Cholestasis and Renal Failure Associated with the Use of the Designer Steroid Superdrol™ (Methasteron™): A Case Report and Literature Review

  title={Severe Cholestasis and Renal Failure Associated with the Use of the Designer Steroid Superdrol{\texttrademark} (Methasteron{\texttrademark}): A Case Report and Literature Review},
  author={John Nasr and Jawad Ahmad},
  journal={Digestive Diseases and Sciences},
  • J. Nasr, J. Ahmad
  • Published 1 May 2009
  • Medicine
  • Digestive Diseases and Sciences
The use of over the counter (OTC) nutritional supplements is widespread among amateur bodybuilders. Reports suggest that up to 30% of people who train regularly with weights use androgenic/anabolic steroids (AAS) and that a significant percentage of male high school students use AAS, not just for muscle gain but also to improve their physical appearance [1, 2]. The use of AAS is associated with a variety of potential liver injuries including toxic hepatitis and cholestasis [3, 4] but is often… 
Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review
AKI is an important complication of anabolic steroid and vitamin supplement abuse and the main cause of renal dysfunction in these cases seems to be the vitamin D intoxication and drug-induced interstitial nephritis.
Cholestatic jaundice, acute kidney injury and acute pancreatitis secondary to the recreational use of methandrostenolone: a case report
A 50-year-old man of Indian descent who presented with a six week history of diffuse abdominal pain, anorexia and weight loss following an eight week cycle of methandrostenolone use is reported.
Successful Use of N‐Acetylcysteine to Treat Severe Hepatic Injury Caused by a Dietary Fitness Supplement
A 20‐year‐old Hispanic male who presented with acute nausea and vomiting accompanied by severe right upper quadrant abdominal pain, shivering, and shortness of breath was diagnosed with acute drug‐induced liver injury secondary to the use of “Friction,” a bodybuilding supplement.
Androgenic anabolic steroid-induced liver injury: two case reports assessed for causality by the updated Roussel Uclaf Causality Assessment Method (RUCAM) score and a comprehensive review of the literature
Physicians are likely to encounter AAS DILI and Causality assessment using the updated RUCAM should be performed but defining indications and proving efficacy for therapies remains challenging.
Treatments for people who use anabolic androgenic steroids: a scoping review
There is scarce evidence on treating dependence, managing withdrawal, or initiating behaviour change in users in any settings, and evidence is urgently required to support the development of effective services for users and of evidence-based guidance and interventions to respond to users in a range of healthcare settings.
Designer steroids – over‐the‐counter supplements and their androgenic component: review of an increasing problem
It is proposed that the impact of AAS use on the reproductive and hormonal health of men is underestimated in the literature owing to previous studies’ failure to account for designer steroid use.
The treatment of toxic effects after androgenic anabolic steroid misuse includes combination of extracorporea l detoxification of cumulated bilirubin, hyperbaric oxygen therapy and hepatoprotective agents.
Hepatic Ductopenia and Vanishing Bile Duct Syndrome Following Anabolic Androgenic Steroid Use: A Case Report and Literature Review.
A case of VBDS associated with anabolic androgenic steroid (AAS) exposure in an otherwise healthy 29-year-old male presented to a local urgent care centre with a six-day history of progressive jaundice, pruritus, mild abdominal bloating and nausea.
HypothesisPotentially harmful advantage to athletes : a putative connection between UGT 2 B 17 gene deletion polymorphism and renal disorders with prolonged use of anabolic androgenic steroids
It is hypothesized that UGT2B17 deficient individuals are more vulnerable to developing renal disorders with prolonged use of AAS owing to increases in body mass index and possible direct toxic effects of steroids on the kidneys, and benefit harm evaluations in therapeutic use of anabolic steroids should also consider this potential link between UGT1B17 gene deletion polymorphism and renal disorders.


Androgenic/anabolic steroid-induced intrahepatic cholestasis: a review with four additional case reports.
Four cases of severe cholestasis attributed to anabolic/androgenic steroid usage demonstrate that drug-induced cholESTasis can be prolonged, can mimic advanced liver disease, and can be associated with co-existent renal dysfunction.
Hepatocellular adenomas associated with anabolic androgenic steroid abuse in bodybuilders: a report of two cases and a review of the literature
Sportsmen taking AAS should be considered as a group at risk of developing hepatic sex hormone related tumours and should be carefully and periodically monitored with US studies.
Androgenic/Anabolic steroid-induced toxic hepatitis.
This case is the first case of toxic hepatitis induced by androgenic/anabolic steroids with predominantly hepatocellular necrosis instead of intrahepatic cholestasis and the much higher values of AST and ALT levels than reported in other studies are presented.
Cholestatic Jaundice and IgA Nephropathy Induced by OTC Muscle Building Agent Superdrol
A case of jaundice and IgA nephropathy as a consequence of use of a muscle enhancing OTC supplement that was advertised as innocuous with no hormonal activity is described.
Anabolic–androgenic steroids and liver injury
A representative case of intrahepatic cholestasis is described with the intention to discuss AAS‐related liver toxicity (including the potential therapeutic role of ursodeoxycholic acid) and to comment on several aspects of the clinical scenario the gastroenterologist should be aware of.
Anabolic androgenic steroids: a survey of 500 users.
AAS users in this sample are taking larger doses than previously recorded, with more than half of the respondents using a weekly AAS dose in excess of 1000 mg, and several trends in the nonmedical use of AAS are revealed.
Anabolic-Androgenic Steroids
The existing scientific evidence coupled with an overwhelming number of anecdotal accounts argues against devoting significant resources to this area of investigation at present, and efforts should be expanded in the areas of prevention and education.
Adverse effects of anabolic steroids in athletes. A constant threat.
Side effects of anabolic androgenic steroids abuse.
The most important long-term adverse effects were lower fertility and the impairment of lipid profile associated with an increased cardiovascular risk.
Prevalence and risk factors for anabolic-androgenic steroid abuse in Australian high school students.
It is concluded that AAS abuse is relatively uncommon among Australian high school students but has distinctive and strong socio-economic and cultural predictors.