Severe Candida spp. infections: new insights into natural immunity.

  title={Severe Candida spp. infections: new insights into natural immunity.},
  author={Jos W M van der Meer and Frank L van de Veerdonk and Leo A B Joosten and B. -J. Kullberg and Mihai G Netea},
  journal={International journal of antimicrobial agents},
  volume={36 Suppl 2},
Invasive infections caused by Candida spp. are associated with high mortality. Colonisation by Candida spp. and the capacity of the host to recognise them as potential pathogens are essential steps in the development of these infections. The major pathogen-associated molecular patterns of Candida are mannoproteins, glucans and chitins, which are recognised by C-type lectin pattern recognition receptors such as the mannose receptor, dectin-1 and dectin-2. By the secretion of proteases and toxins… CONTINUE READING