Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy.

@article{Guadalupe2003SevereCT,
  title={Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy.},
  author={Moraima Guadalupe and Elizabeth Reay and Sumathi Sankaran and Thomas Prindiville and Jason A Flamm and Andrew McNeil and Satya Dandekar},
  journal={Journal of virology},
  year={2003},
  volume={77 21},
  pages={11708-17}
}
Gut-associated lymphoid tissue (GALT) harbors the majority of T lymphocytes in the body and is an important target for human immunodeficiency virus type 1 (HIV-1). We analyzed longitudinal jejunal biopsy samples from HIV-1-infected patients, during both primary and chronic stages of HIV-1 infection, prior to and following the initiation of highly active antiretroviral therapy (HAART) to determine the onset of CD4(+) T-cell depletion and the effect of HAART on the restoration of CD4(+) T cells… CONTINUE READING
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