Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inherited thiopurine methyltransferase deficiency.

@article{McBride2000Severe6M,
  title={Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inherited thiopurine methyltransferase deficiency.},
  author={Kim L McBride and Gerald S. Gilchrist and William Anthony Smithson and Richard M. Weinshilboum and Carol L. Szumlanski},
  journal={Journal of pediatric hematology/oncology},
  year={2000},
  volume={22 5},
  pages={
          441-5
        }
}
6-thioguanine (6TG) is undergoing investigation for use in the maintenance phase of acute lymphoblastic leukemia (ALL). Just as with 6-mercaptopurine (6MP), it is be expected that 6TG would cause pancytopenia in individuals with inherited thiopurine methyltransferase (TPMT) deficiency. We report the first case of severe and prolonged pancytopenia caused by 6-thioguanine in an 8-year-old boy with ALL and inherited TPMT deficiency. Neutropenia lasted 67 days, whereas anemia and thrombocytopenia… CONTINUE READING
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