Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy.

  title={Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy.},
  author={T. Dianne Langford and Scott L Letendre and Thomas D. Marcotte and Ronald J Ellis and John McCutchan and Igor Grant and Margaret E Mallory and Lawrence Arthur Hansen and Sarah L. Archibald and Terry L. Jernigan and Eliezer Masliah},
  volume={16 7},
OBJECTIVES To describe a severe form of demyelinating HIV-associated leukoencephalopathy in AIDS patients failing highly active antiretroviral therapy (HAART), its relationship to clinical and neuroimaging findings, and suggest hypotheses regarding pathogenesis. DESIGN AND METHODS AIDS patients who failed HAART and displayed severe leukoencephalopathy were included. All cases had detailed neuromedical, neuropsychological, neuroimaging and postmortem neuropathological examination… CONTINUE READING


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