Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?

  title={Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?},
  author={Sebastiaan Kuhne and Maikel Wijtmans and Herman D. Lim and Rob Leurs and Iwan J.P. de Esch},
  journal={Expert opinion on investigational drugs},
  volume={20 12},
INTRODUCTION The histamine H(3) receptor (H(3)R) plays a pivotal role in a plethora of therapeutic areas. Blocking the H(3)R with antagonists/inverse agonists has been postulated to be of broad therapeutic use. Indeed, H(3)R antagonists/inverse agonists have been extensively evaluated in the clinic. AREAS COVERED Here, we address new developments, insights obtained and challenges encountered in the clinical evaluations. For recent H(3)R clinical candidates, the status and results of the… CONTINUE READING
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