Seven-year clinical follow-up of premanifest carriers of Huntington's disease

@inproceedings{Hart2011SevenyearCF,
  title={Seven-year clinical follow-up of premanifest carriers of Huntington's disease},
  author={Ellen P. Hart and Huub A. M. Middelkoop and Caroline K. Jurgens and Marie-No{\"e}lle W. Witjes-An{\'e} and Raymund A. C. Roos},
  booktitle={PLoS currents},
  year={2011}
}
Detecting subtle clinical abnormalities in the 'premanifest' phase of Huntington's disease (HD) is of importance in the development of instruments to monitor early therapeutic intervention trials. The current study examined changes in motor function, cognition and behaviour over a period of seven years in premanifest carriers of the HD gene mutation. Twenty-nine carriers without unequivocal motor signs of HD and 43 non-carrier controls were prospectively examined four times. The assessments… CONTINUE READING
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