Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

  title={Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study},
  author={Zsofia Kote-Jarai and Ali Amin Al Olama and Graham G. Giles and Gianluca Severi and Johanna Schleutker and Maren Weischer and Daniele Campa and Elio Riboli and Timothy J Key and Henrik Gronberg and David J. Hunter and Peter Kraft and Michael J. Thun and Sue Ann Ingles and Stephen J. Chanock and Demetrius Albanes and Richard B Hayes and David E. Neal and Freddie Hamdy and Jenny L Donovan and Paul D. P. Pharoah and Fredrick R Schumacher and Brian E. Henderson and Janet L. Stanford and Elaine A Ostrander and Karina Dalsgaard Sorensen and Thilo D{\"o}rk and Gerald L. Andriole and Joanne L Dickinson and Cezary Cybulski and Jan A. Lubiński and Amanda B Spurdle and Judith Ann Clements and Suzanne K Chambers and Joanne Aitken and Robert Frank A Gardiner and Stephen N. Thibodeau and Dan Schaid and Esther M John and Christiane Maier and Walther Vogel and Kathleen A Cooney and Jong Y. Park and Lisa A. Cannon-Albright and Hermann Brenner and Tomonori Habuchi and Hongwei Zhang and Yong-Jie Lu and Radka Kaneva and Ken W Muir and Sara Benlloch and Daniel A. Leongamornlert and Edward J. Saunders and Malgorzata Tymrakiewicz and Nadiya Mahmud and Michelle R. Guy and Lynne T O'Brien and Rosemary A. Wilkinson and Amanda L Hall and Emma J. Sawyer and Tokhir Dadaev and Jonathan Morrison and David. P. Dearnaley and Alan H. Horwich and Robert A Huddart and Vincent Khoo and Christopher C. Parker and Nicholas J Van As and Christopher R J Woodhouse and Alan Thompson and Tim J Christmas and Chris Ogden and Colin S Cooper and Aritaya Lophatonanon and Melissa C. Southey and John L. Hopper and Dallas English and Tiina A Wahlfors and Teuvo L. J. Tammela and Peter Klarskov and B{\o}rge G. Nordestgaard and Martin Andreas R{\o}der and Anne Tybj{\ae}rg-Hansen and Stig Egil Bojesen and Ruth C. Travis and Frederico Canzian and Rudolf Kaaks and Fredrik Wiklund and Mohammed Z. Y. Aly and Sara Lindstrom and W Ryan Diver and Susan M Gapstur and Mariana Carla Stern and R. Prieto Corral and Jarmo R Virtamo and Angela Cox and Christopher A. Haiman and Loic Le Marchand and L M FitzGerald and Suzanne Kolb and Erika M. Kwon and Danielle M. Karyadi and Torben F. {\O}rntoft and Michael Borre Borre and Andreas Meyer and Juergen Serth and Meredith Yeager and Sonja I. Berndt and James R. Marthick and Briony Patterson and Dominika Wokolorczyk and Jyotsna Batra and Felicity A. Lose and Shannon K. McDonnell and Amit D Joshi and Ahva Shahabi and Antje E. Rinckleb and Ana Ray and Thomas A. Sellers and Hui-Yi Lin and Robert A. Stephenson and James S Farnham and Heiko Muller and Dietrich Rothenbacher and Norihiko Tsuchiya and Shintaro Narita and Guangwen Cao and Chavdar Slavov and Vanio Iv. Mitev and Douglas F. Easton and Rosalind A. Eeles},
  journal={Nature Genetics},
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30… CONTINUE READING
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Meta-analysis of genome-wide scans for human adult stature identifies novel loci and associations with measures of skeletal frame size

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  • PLoS Genet. 5,
  • 2009

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