Seven novel point mutations in the F11 gene in Iranian FXI-deficient patients.

@article{FardEsfahani2008SevenNP,
  title={Seven novel point mutations in the F11 gene in Iranian FXI-deficient patients.},
  author={Pezhman Fard-Esfahani and Ghasem Rastegar Lari and Shirin Ravanbod and Fatemeh Mirkhani and Mojgan Allahyari and Maryam Rassoulzadegan and Fereydoun Ala},
  journal={Haemophilia : the official journal of the World Federation of Hemophilia},
  year={2008},
  volume={14 1},
  pages={91-5}
}
Factor XI (FXI) deficiency disorder is caused by defects in the F11 gene. The affected patients may suffer unexpected and major bleeding after trauma. Hence, the aim of this study was to identify the mutations underlying FXI deficiency in Iranian patients. The genetic basis of FXI deficiency was investigated in nine Iranian patients from unrelated families… CONTINUE READING