Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins.

@article{Maeda1996SevenHC,
  title={Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins.},
  author={Masahiro Maeda and Laurence Aubry and Robert H. Insall and C Gaskins and Peter N. Devreotes and Richard A. Firtel},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 7},
  pages={
          3351-4
        }
}
Mitogen-activated protein (MAP) kinases are involved in controlling a cell's responses to a variety of stimuli and can be activated by both protein tyrosine kinase and G protein-coupled receptors. It was shown previously that Dictyostelium MAP kinase ERK2 is required for normal activation of adenylyl cyclase and erk2 null cells are aggregation-deficient. In this manuscript, we show that the Dictyostelium MAP kinase ERK2 is rapidly and transiently activated in response to the chemoattractant… CONTINUE READING

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