Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium.

  title={Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium.},
  author={Michael F Freeman and Maximilian J Helf and Agneya Bhushan and Brandon I Morinaka and J{\"o}rn Piel},
  journal={Nature chemistry},
  volume={9 4},
Uncultivated bacteria represent a massive resource of new enzymes and bioactive metabolites, but such bacteria remain functionally enigmatic. Polytheonamides are potent peptide cytotoxins produced by uncultivated bacteria that exist as symbionts in a marine sponge. Outside glycobiology, polytheonamides represent the most heavily post-translationally modified biomolecules that are derived from amino acids. The biosynthesis of polytheonamides involves up to 50 site-specific modifications to… CONTINUE READING
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