Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP.

@article{Bader2007SevenDD,
  title={Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP.},
  author={Sonya Bader and Arjan Kortholt and Peter J M van Haastert},
  journal={The Biochemical journal},
  year={2007},
  volume={402 1},
  pages={153-61}
}
The Dictyostelium discoideum genome uncovers seven cyclic nucleotide PDEs (phosphodiesterases), of which six have been characterized previously and the seventh is characterized in the present paper. Three enzymes belong to the ubiquitous class I PDEs, common in all eukaryotes, whereas four enzymes belong to the rare class II PDEs that are present in bacteria and lower eukaryotes. Since all D. discoideum PDEs are now characterized we have calculated the contribution of each enzyme in the… CONTINUE READING