Sevelamer prevents uremia-enhanced atherosclerosis progression in apolipoprotein E-deficient mice.

@article{Phan2005SevelamerPU,
  title={Sevelamer prevents uremia-enhanced atherosclerosis progression in apolipoprotein E-deficient mice.},
  author={Olivier Phan and Ognen Ivanovski and Thao Nguyen-Khoa and Nadya Mothu and Jes{\'u}s Angulo and Ralf Westenfeld and Markus Ketteler and Natalie Meert and Julien Maizel and Igor G. Nikolov and Raymond Camille Vanholder and Bernard Lacour and Tilman Bernhard Dr{\"u}eke and Ziad A Massy},
  journal={Circulation},
  year={2005},
  volume={112 18},
  pages={
          2875-82
        }
}
BACKGROUND The novel phosphate binder sevelamer has been shown to prevent the progression of aortic and coronary calcification in uremic patients. Whether it also decreases the progression of atheromatous plaques is unknown. The aim of our study was to examine the effect of sevelamer administration on the development of atherosclerosis and aortic calcification in the uremic apolipoprotein E-deficient mouse as an established model of accelerated atherosclerosis. METHODS AND RESULTS Female mice… CONTINUE READING

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