Setting the stage: possible mechanisms by which acute contraction restores insulin sensitivity in muscle.

  title={Setting the stage: possible mechanisms by which acute contraction restores insulin sensitivity in muscle.},
  author={John P. Thyfault},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={294 4},
  • J. Thyfault
  • Published 23 January 2008
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
It has long been known that acute exercise can dramatically improve insulin sensitivity in previously insulin-resistant muscle; however, the precise mechanisms underlying this clinically significant interaction remain unknown. Using hindlimb perfusions in obese Zucker rats, our group found that acute muscle contraction synergistically improved insulin-stimulated glucose transport in skeletal muscle, but contrary to our hypothesis, these findings were not associated with either improved insulin… 

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