Setting the Record Straight: The Origin of the Pharmacophore Concept

@article{Gner2014SettingTR,
  title={Setting the Record Straight: The Origin of the Pharmacophore Concept},
  author={Osman F. G{\"u}ner and J. Phillip Bowen},
  journal={Journal of chemical information and modeling},
  year={2014},
  volume={54 5},
  pages={1269-83}
}
For over a century since the early 1900s, Paul Ehrlich was credited with originating the concept of pharmacophores. This was challenged by John Van Drie in 2007 due to the fact that Ehrlich did not use the word "pharmacophore" in his writings. Van Drie claimed that the attribution of the pharmacophore concept to Ehrlich was due to an erroneous citation made by Ariëns in a 1966 paper, and instead he claimed, Lemont B. Kier developed the pharmacophore concept (in the modern sense, as defined by… CONTINUE READING