Setipiprant, a selective CRTH2 antagonist, reduces allergen‐induced airway responses in allergic asthmatics
@article{Diamant2014SetipiprantAS, title={Setipiprant, a selective CRTH2 antagonist, reduces allergen‐induced airway responses in allergic asthmatics}, author={Z. Diamant and P. Sidharta and D. Singh and B. J. O'connor and R. Zuiker and B. Leaker and M. Silkey and J. Dingemanse}, journal={Clinical & Experimental Allergy}, year={2014}, volume={44}, pages={1044 - 1052} }
CRTH2 is a G‐protein‐coupled receptor on T helper2 cells that mediates pro‐inflammatory effects of prostaglandin D2 in allergic responses.
Topics from this paper
70 Citations
The effects of the novel SHIP1 activator AQX‐1125 on allergen‐induced responses in mild‐to‐moderate asthma
- Medicine
- Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
- 2014
- 34
A phase 2 study to evaluate the safety, efficacy and pharmacokinetics of DP2 antagonist GB001 and to explore biomarkers of airway inflammation in mild‐to‐moderate asthma
- Medicine
- Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
- 2019
- 5
CRTH2 antagonists in asthma: current perspectives
- Medicine
- Clinical pharmacology : advances and applications
- 2017
- 25
- PDF
The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy
- Biology, Medicine
- International journal of molecular sciences
- 2020
- 4
- PDF
Targeting the PGD2/CRTH2/DP1 Signaling Pathway in Asthma and Allergic Disease: Current Status and Future Perspectives
- Medicine
- Drugs
- 2017
- 47
- PDF
The effect of the novel SHIP1 activator AQX-1125 on allergen-induced responses in mild to moderate asthma
- Medicine
- 2013
- 1
Current perspective on eicosanoids in asthma and allergic diseases: EAACI Task Force consensus report, part I
- Medicine
- Allergy
- 2020
- 6
Prostaglandin D2 receptor antagonists in allergic disorders: safety, efficacy, and future perspectives
- Medicine
- Expert opinion on investigational drugs
- 2019
- 18
Investigational prostaglandin D2 receptor antagonists for airway inflammation
- Medicine
- Expert opinion on investigational drugs
- 2016
- 17
References
SHOWING 1-10 OF 37 REFERENCES
A randomized, double‐blind, placebo‐controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma
- Medicine
- Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
- 2012
- 186
The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo‐controlled, double‐blind trial
- Medicine
- Allergy
- 2012
- 70
- PDF
Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases
- Biology, Medicine
- Nature Reviews Drug Discovery
- 2007
- 260
Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459
- Medicine
- European Respiratory Journal
- 2012
- 81
- PDF
Anti‐eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis
- Medicine
- Allergy
- 2013
- 156
Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients.
- Medicine
- The Journal of allergy and clinical immunology
- 2013
- 76
Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation
- Medicine
- Respiratory research
- 2007
- 113
- PDF
The roles of the prostaglandin D2 receptors DP1 and CRTH2 in promoting allergic responses
- Medicine, Chemistry
- British journal of pharmacology
- 2008
- 139
- PDF
Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction.
- Medicine
- Journal of applied physiology
- 1989
- 133
A novel PGD(2) receptor expressed in eosinophils.
- Chemistry, Medicine
- Prostaglandins, leukotrienes, and essential fatty acids
- 2003
- 23